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1994-10-25
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Document 3049
DOCN M94A3049
TI Progressive biological markers of HIV infection depending on different
risk groups and CDC stages.
DT 9412
AU Fuster M; Martinez C; Cortes M; Cadafalch J; Domingo P; Barrio J;
Sambeat MA; Internal Medicine Department, Programa SANT PAUCITRAN,
Hospital; de Sant Pau, Barcelona, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):165 (abstract no. PB0088). Unique
Identifier : AIDSLINE ICA10/94369526
AB OBJECTIVE: To study the biological parameters of HIV progressive
infection depending on different risk groups. METHOD: Different
biological parameters (B2-M, neopterine, CD4 linfocites, triglicerides,
IgA and ADA) have been studied in a sample of 524 HIV+ patients. From
the first blood extraction the patients were divided into four different
risk groups: 75 heterosexuals, 107 homosexuals, 220 ex IDU and 122
active IDU. Following the CDC criteria for their classification, 360
pacients belonged to the group II-III, 71 patients were IVc2 and 93
patients were IVc1. The four risk groups were showing similar
characteristics on the different stages, only statistical significant
differences were found in the IVc2 group which was higher in the group
of patients who had been infected by the way they took drugs (IDU).. The
data were interrelated depending on the risk group and on the CDC stage.
Statistical analyses were performed with the Statgraph Statistical
Package. RESULTS: All the different parameters being studied were
statistically significant, higher in the 93 patients belonging to the
IVc1 group (AIDS), except for the ADA in serum which was higher in the
IVc2 patients. Independently from the CDC stage the values for the
B2-microglobuline were significatively higher in the group of patients
showing an active addiction (p = 0.047); neopterine in the heterosexual
group (p = 0.0007); ADA in the group of IDU (p = 0.0000). Neither CD4
linfocites nor triglicerides showed any statisticaly significant
differences. When relating these data depending on the CDC stage of
infection: B2-microglobuline was significatively higher in the II-III
stage in the active IDU group (P = 0.0020) and in the IVc1 stage in the
homosexual group. Neopterine was significatively higher in the
homosexual group depending both on the II-III stage (p = 0.0464) and in
the IVc1 (p = 0.0014). IgA was higher in the II-III stage both in the
heterosexual and in the homosexual groups (p = 0.0057) without any
significant differencies depending neither on the IVc1 nor on the IVc2.
ADA values were higher in the II-III in the active IDU(p = 0.0001) and
no statisticaly significant difference as found neither in the group
IVc1 nor in the IVc2. CONCLUSION: Among asymptomatic patients the B2-M
values are higher if and active IDU addiction is present at the moment,
while IgA values were higher in the sexual transmission groups (homo and
heterosexual) and ADA was so in the parenteral group of risk. Neopterine
was higher in the homosexual group through all the stages.
DE beta 2-Microglobulin/METABOLISM Acquired Immunodeficiency
Syndrome/CLASSIFICATION/DIAGNOSIS/ TRANSMISSION Biological
Markers/*BLOOD Biopterin/ANALOGS & DERIVATIVES/BLOOD Female
Homosexuality Human HIV
Infections/CLASSIFICATION/*DIAGNOSIS/TRANSMISSION IgA/BLOOD Leukocyte
Count Male Risk Factors Substance Abuse,
Intravenous/COMPLICATIONS/IMMUNOLOGY Triglycerides/BLOOD T4
Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).